glp1versus

Trulicity vs Victoza

dulaglutide (GLP-1 receptor agonist) vs liraglutide (GLP-1 receptor agonist) — a complete side-by-side comparison.

Eli LillyNovo Nordisk

Trulicity weight loss

3.1%

Victoza weight loss

3.2%

Trulicity dosing

Once weekly

Victoza dosing

Once daily

Reviewed by Dr. Elena Vance, DOLast reviewed 4 sources cited

Quick Summary

Trulicity (dulaglutide) and Victoza (liraglutide) are both glp-1 receptor agonists. In clinical trials, Victoza showed greater weight loss (3.2% vs 3.1%).

See the comparison table below for detailed side-by-side data.

Trulicity vs Victoza: Full Comparison

FeatureTrulicity(dulaglutide)Victoza(liraglutide)
Active Ingredientdulaglutideliraglutide
Drug ClassGLP-1 receptor agonistGLP-1 receptor agonist
ManufacturerEli LillyNovo Nordisk
FDA Approved2014-09-182010-01-25
Approved Indications
  • Type 2 diabetes mellitus (adjunct to diet and exercise)
  • Reduction of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors
  • Type 2 diabetes mellitus (adjunct to diet and exercise)
  • Reduction of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease
  • Type 2 diabetes in patients aged 10+ years
Routesubcutaneous injectionsubcutaneous injection
FrequencyOnce weeklyOnce daily
Starting Dose0.75 mg weekly0.6 mg daily
Maintenance Dose1.5 mg weekly1.2 mg or 1.8 mg daily
Max Dose4.5 mg weekly1.8 mg daily
Weight Loss (%)3.1%3.2%
A1C Reduction1.5%1.1%
Key TrialREWIND (260 weeks)LEADER (188 weeks)
List Price$950-$1,100/month$950-$1,100/month
With Insurance$25-$150/month (varies by plan)$25-$150/month (varies by plan)
Savings Card$25/month (Lilly savings card, commercially insured)$25/month (Novo Nordisk savings card, commercially insured)

Side Effects: Trulicity vs Victoza

Side EffectTrulicityVictoza
Nausea12-21%28%
Diarrhea8-13%17%
Vomiting6-12%11%
Abdominal pain6-9%Not reported
Decreased appetite4-9%9%
Dyspepsia4-6%7%
Fatigue4-6%Not reported
Pancreatitis (rare)<0.5%<1%
HeadacheNot reported9%
ConstipationNot reported6%

Severity scale: 1 (mild) to 5 (serious). Based on FDA prescribing information and clinical trial data.

Related Comparisons

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Frequently Asked Questions

Sources & References

  1. Trulicity FDA prescribing information
  2. Victoza FDA prescribing information
  3. Gerstein HC et al., Lancet 2019;394:121-130. FDA prescribing information.
  4. Marso SP et al., N Engl J Med 2016;375:311-322. FDA prescribing information.

This content is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions. See our full medical disclaimer.